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Background: Traditional calorimetry methods face significant limitations in analyzing small-scale energy exchanges in biological and pharmaceutical applications. Current technologies require large sample volumes and lack the sensitivity needed for studying minute energy changes in biomolecular interactions. Conventional differential scanning calorimeters are often bulky, expensive, and require specialized facilities for operation. The inability to perform highly sensitive measurements on small samples limits their application in drug discovery, where sample availability may be restricted and precise thermodynamic analysis is crucial for understanding molecular interactions.
Technical Overview: Northeastern researchers have developed an innovative photonic-based differential scanning calorimeter that utilizes Extraordinary Optical Transmission (EOT) through nanohole arrays for ultra-sensitive energy exchange measurements. This technology achieves unprecedented sensitivity levels of 5 picojoules while requiring minimal sample volumes. The system employs advanced photonic principles to detect minute temperature changes and energy exchanges during biomolecular interactions. The platform enables wireless, non-contact measurements and can be integrated into automated screening systems for high-throughput analysis.
Benefits:
- Achieves ultra-high sensitivity (5 picojoules) with minimal sample volume
- Enables wireless, non-contact measurements
- Provides real-time analysis of biomolecular interactions
- Compact design suitable for various laboratory environments
- Cost-effective alternative to traditional calorimetry methods
Application:
- Drug Discovery: Early-stage compound screening and analysis
- Protein Research: Investigation of protein folding and interactions
- Pharmaceutical Development: Thermodynamic analysis of drug-target interactions
- Biomolecular Studies: Characterization of molecular binding events
Opportunity: Open for licensing.
