Bio-inspired proline sensors for diagnosis and surveillance of stress in living systems

Background: Controlling environmental conditions is critical for the production of agricultural crops, including food and plant-based commodities. To prevent massive loss of crops, farmers need to receive timely information about plant stress conditions. Proline is a key biomarker that accumulates in plants under various stress conditions, including drought, salinity, temperature extremes, and heavy metal exposure. Traditional methods for measuring proline require laboratory equipment and specialized training, making them impractical for field use. The need for simple, rapid, and cost-effective stress monitoring tools is essential for modern agriculture and crop management.

Technical Overview: This paper-based proline sensor can be used to analyze proline levels from plants and other food products. The user soaks the plant material in the provided liquid and adds the liquid to the sensor's sample well. The sensor produces a color change that can be read visually or with a smartphone app to determine proline concentrations. The system is based on bio-inspired colorimetric detection principles that provide rapid, quantitative results without requiring laboratory equipment. The sensor is designed to be stable, portable, and easy to use in field conditions.

Benefits:

  • Disposable, paper-based
  • Customizable
  • Small size, portable
  • Easy to read color change from green to red
  • No laboratory equipment required

Application:

  • Detects plant stress due to drought, excess salinity, heavy metals, temperature extremes, UV and other radiation
  • Agricultural monitoring and crop management
  • Food quality assessment
  • Environmental stress monitoring

Opportunity:

  • License
  • Research collaboration
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
BIO-INSPIRED PROLINE SENSORS FOR DIAGNOSIS AND SURVEILLANCE OF STRESS IN LIVING SYSTEMS Utility *United States of America 19/228,723   6/4/2025     Pending
For Information, Contact:
Vaibhav Saini
Senior Manager Commercialization
Northeastern University
v.saini@northeastern.edu
Patent #
Inventors:
Cassandra Martin
Daniel Wilson
Josephine Cicero
Audrey Moos
Dorthea Geroulakos
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